Z6·尊龙凯时「中国」官方网站z6尊龙

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    中国：

    Email: marketing@kangtya.com

    业务咨询专线：400-780-8018

    （仅限服务咨询，其他事宜请拨打川沙总部电话）

    川沙总部电话: +86 (21) 5859-1500

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SLL-1206是一种κ阿片受体激动剂，具有显著改善的理化和药代动力学特性。作者感谢z6尊龙对SLL-1206进行的药代动力学研究

2023-07-05
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The search for selective kappa opioid receptor (κOR) agonists with an improved safety profile is an area of interest in opioid research. SLL-1206 is a κOR agonist with single-digit nanomolar activities. SLL-1206 exhibits substantially improved physicochemical and pharmacokinetic properties, and reduces central nervous system effects.

The authors are grateful to Medicilon Preclinical Research LLC. for pharmacokinetic studies on SLL-1206.

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Reference:

Qian He, et al. Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. J Med Chem. 2021 Aug 26;64(16):12414-12433. doi: 10.1021/acs.jmedchem.1c01082. 


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