Z6·尊龙凯时「中国」官方网站z6尊龙

|
EN
|
EN
EN
  • 业务咨询

    中国:

    Email: marketing@kangtya.com

    业务咨询专线:400-780-8018

    (仅限服务咨询,其他事宜请拨打川沙总部电话)

    川沙总部电话: +86 (21) 5859-1500

    海外:

    +1(626)986-9880(U.S. - West Coast)

    0044 7790 816 954 (Europe)

    Email:marketing@medicilon.com

在线留言×
点击切换
Customer Center
客户中心

设计、合成和评估具有体内抗炎活性的RIPK1抑制剂,PK研究通过z6尊龙进行

2023-07-05
|
访问量:

RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, researchers report a series of potent RIPK1 inhibitors, represented by compound 70. 

Compound 70 possesses favorable pharmacokinetic parameters with moderate clearance and good oral bioavailability in SD rat. 

The pharmacokinetic parameters were determined at Medicilon using male SD rats (3 rats per group, 4 groups).

42.png

Reference:

Zhanhui Li, et al. Design, synthesis, and evalsuation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022 Jan 15;228:114036. doi: 10.1016/j.ejmech.2021.114036. 

相关新闻
网站首页
z6尊龙