Z6·尊龙凯时「中国」官方网站z6尊龙

|
EN
|
EN
EN
  • 业务咨询

    中国:

    Email: marketing@kangtya.com

    业务咨询专线:400-780-8018

    (仅限服务咨询,其他事宜请拨打川沙总部电话)

    川沙总部电话: +86 (21) 5859-1500

    海外:

    +1(626)986-9880(U.S. - West Coast)

    0044 7790 816 954 (Europe)

    Email:marketing@medicilon.com

在线留言×
点击切换
Customer Center
客户中心

研究用于肺癌和黑色素瘤细胞肺转移的选择性PAK4抑制剂的合成,此选择性PAK4抑制剂的PK研究通过z6尊龙进行

2023-06-28
|
访问量:

1-Compound-55-is-effective-in-the-treatment-of-metastatic-cancer-1.jpg

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. 6-Ethynyl-1H-indole derivative 55 is a potent and selective PAK4 inhibitor (Ki=10.2 nM). Compound 55 is effective in the treatment of metastatic cancer. The pharmacokinetic study of Compound 55 was carried out by Medicilon.

Reference

Peilu Song, et al. Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells. Acta Pharm Sin B. 2022 Jun;12(6):2905-2922. doi: 10.1016/j.apsb.2022.02.029.

相关新闻
网站首页
z6尊龙