Z6·尊龙凯时「中国」官方网站z6尊龙

|
EN
|
EN
EN
  • 业务咨询

    中国:

    Email: marketing@kangtya.com

    业务咨询专线:400-780-8018

    (仅限服务咨询,其他事宜请拨打川沙总部电话)

    川沙总部电话: +86 (21) 5859-1500

    海外:

    +1(626)986-9880(U.S. - West Coast)

    0044 7790 816 954 (Europe)

    Email:marketing@medicilon.com

在线留言×
点击切换
Customer Center
客户中心

设计合成一系列DHODH抑制剂作为潜在的类风湿性关节炎治疗药物,PK研究通过z6尊龙进行

2023-06-28
|
访问量:

15-DHODH (1).jpg

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases. Herein, researchers designed and synthesized a series of acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA) treatment agents. The most potent compound 54 displays favorable pharmacokinetic (PK) profiles in vivo.

The PK study was conducted by using Medicilon's preclinical pharmacokinetic study services.

Reference

Fanxun Zeng, et al. Design, synthesis, molecular modeling, and biological evalsuation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis. Acta Pharm Sin B. 2020 Oct 15;11(3):795-809. doi: 10.1016/j.apsb.2020.10.008.

相关新闻
网站首页
z6尊龙